A reason to dance. What, you think that the protein above woke up looking that beautiful? To understand how and why a protein folds, it’s important to remind ourselves of how they come to exist in the first place—the central dogma of molecular biology. DNA is transcribed into mRNA, and mRNA is translated in proteins. That probably sounds like an awful lot of alphabet soup, but let’s simplify things with an analogy: your cell is a small company called Cell Incorporated®. Every company needs a CEO to boss everybody around, and that’s “DNA” (deoxyribonucleic acid), whose office is located in the center (nucleus) of Cell Inc.®. However, even a visionary leader is powerless if they cannot communicate that vision, so they employ messengers called “mRNA” (messenger ribonucleic acid). Now, the company needs to produce something to make a profit, and that product is called “proteins.” Ergo, the central dogma of molecular biology: DNA -> mRNA -> proteins.
To make their product, Cell Inc.® needs raw materials—these are chemicals called amino acids, the steel from which proteins are made. As a protein is being constructed (or translated from the “language” of nucleic acids to amino acids), it is formed piece by piece in a long chain. Imagine that every component that makes up a cell phone was attached to one another by a tiny string; if you laid out that string, it would look nothing like a cell phone (let alone work like one), and the same is true for proteins. Unfortunately for them, cells don’t have the benefit of assembly lines and blue collar workers; therefore, the product must put itself together.
Understand the immense difficulty of this task for a moment: Cell Inc.® needs to make a product out of steel blocks connected by string that, due to the unique properties of each block, will self-assemble into something useful, something beautiful (cell phones are beautiful, okay?).
Fortunately for them, however, cells possess the most powerful allies in the entire universe: the laws of physics (c). And it is these laws that govern what is possible, what is probable, and what isn’t. Using physics, Cell Inc.® came up with a solution to make its products self-assemble—to make the pieces of the protein fold nicely together: they dance.
Dancing with purpose. There, I said it: protein folding is dancing. Proteins jiggle, wiggle, twist, and turn, always moving, vibrating, and colliding with themselves and anything else around. Although the motions may be random, the dance itself is done with an immense sense of purpose, guided by the very nature of the protein itself. From chaos and entropy, proteins allow their amino acid bodies to guide their movements towards the native structure, the final, functional form of proteins that we’re familiar with (see the image above). From the very moment that a protein is born, it begins to fold—dancing, you might say, is an integral part of the nature of what it means to be a protein.
There’s an important life lesson to be learned from the humble protein, here. We should allow our natural talents and capabilities to guide our decisions, rather than force upon ourselves choices that deviate from the desires of our hearts. In the early moments of a protein’s birth, it seems impossible to foresee anything of worth or interest arising from a tangled mess of amino acids slapped together, moving erratically in the dark loneliness of a cell. However, perhaps if we live our lives like a protein—following our hearts, listening to our bodies, and maybe even a little dancing—we can find fulfillment, and become the best, most beautiful version of ourselves that we can be.